Session titles
A. Nuclear architecture
B. Chromatin structure and dynamics
C. Transcription, posttranscriptional processes
D. DNA replication, recombination, repair
E. Pathological aspects , therapeutical targets
F. Novel methodical perspectives
Aug. 19.
14.00-18.00 |
Registration, mounting of posters[more...] |
Poster information |
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Posters should be mounted at the time of registration, so that they can be viewed and discussed during and after the opening reception. The size of the posters should not exceed 90x150 cm.
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18.00-18.15 |
Conference opening |
18.15-19.15 |
Nuclear architecture and disease. (Wilhelm Bernhard Medal Lecture 2013) |
W1. |
Tom Misteli (Bethesda, USA)[more...] |
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Wilhelm Bernhard Medal Lecture |
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According to recent communication with Dr. Misteli, his appearance has become uncertain due to a lack of timely approval of his travel by NIH administration. Therefore, the schedule of the opening ceremony is subject to change, depending on the success of the efforts at NIH to resolve the situation.
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A. Nuclear architecture
19.15-19.50 A1. | Nuclear organization in lymphoid cells: implications for translocations and gene regulation. | Yegor S. Vassetzky (Paris, France) |
19.50-22.30 |
Welcome reception, poster viewing |
Aug. 20.
A. Nuclear architecture
This session is offered to the memory of Ilya Zbarsky, one of the pioneers of research on nuclear architecture.[more...]
Ilya Zbarsky |
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2013 is the year of centenary of Prof. Ilya Zbarsky (1913-2007), a Russian scientist who pioneered research on nuclear architecture. Integrating biochemistry and cellular biology of the nucleus, he significantly contributed to the formulation of the concept of the nuclear matrix. Dr. Zbarsky was one of active participants and organizers of Wilhelm Bernhard Workshops.
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Chairman: Anna von Mikecz |
08.30-09.05 A2. | From cell populations to single molecule analysis of chromosome folding. (Plenary lecture) | Peter Fraser (Cambridge, UK) |
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09.05-09.30 A3. | New models of the nucleus and chromosomes. | Ronald Hancock (Québec, Canada) |
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09.30-09.55 A4. | An interaction between telomeres and the nucleoskeleton affects chromosome structure. | Steven Kosak (Chicago, USA) |
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09.55-10.20 A5. | Involvement of nuclear phospholipids in nuclear structure and functions. | Pavel Hozák (Prague, Czech Republic) |
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10.20-10.35
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Chairman: Ronald Hancock |
10.35-11.00 A6. | Regulation of aging and metabolism by the C. elegans nuclear lamina. | Yosef Gruenbaum (Jerusalem, Israel) |
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11.00-11.25 A7. | The role of eukaryotic genome spatial organization in regulation of transcription. | Sergey Razin (Moscow, Russia) |
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11.25-11.50 A8. | Large scale chromatin organization: the case of PcG bodies. | Ivan Raska (Prague, Czech Republic) |
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11.50-11.55
| Reminiscences to Prof. Zbarsky | Yegor S. Vassetzky (Paris, France) |
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12.00-13.30
| Lunch, poster viewing | |
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Chairman: Beáta G. Vértessy |
13.30-13.55 A9. | New model of nuclear pore complexes based on lipid-DNA interactions. | Vasily V. Kuvichkin (Moskow, Russia) |
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13.55-14.20 A10. | Putative plant homologs of lamins in plants. | Susana Moreno Díaz de la Espina (Madrid, Spain) |
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14.20-14.45 A11. | Actin family proteins involved in the functional organization of the nucleus. | Masahiko Harata (Sendai, Japan) |
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14.45-15.10 A12. | Nuclear function of a cytoskeletal actin binding protein, Moesin. | Péter Vilmos (Biological Research Center, Szeged, Hungary) |
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15.10-15.25
| Break | |
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B. Chromatin structure and dynamics
Chairman: Susana Moreno Díaz de la Espina |
15.25-16.00 B1. | Chromatin replication and epigenome maintenance. (EMBO Young Investigator lecture) | Anja Groth (Copenhagen, Denmark) |
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16.00-16.25 B2. | Reconstitution of the human nuclear proteome after cell division through NLS modulation. | Beáta G. Vértessy (Budapest, Hungary) |
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16.25-16.50 B3. | Human inactive X chromosome is compacted through a Polycomb-independent SMACHD1-HBIX1 pathway governed by XIST RNA. | Chikashi Obuse (Hokkaido, Japan) |
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16.50-17.15 B4. | Lodestar loads the cohesin complex onto the chromosomes in Drosophila. | János Szabad (Szeged, Hungary) |
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17.15-17.40 B5. | Nucleosome-nucleosome stacking: a major element of chromatin structure. | Nikolay Korolev (Nanayng, Singapore) |
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Evening
| Free program, cultural and touristic events of the Debrecen Flower Carnival 2013[more...] and the Czech Beer Festival[more...] | |
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Flower Carnival |
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As part of the national holiday celebrations on the 20th August the Debrecen Flower Carnival has always been one of the most popular and spectacular festivals in Hungary. The history of the Flower Carnival dates back to the beginning of the 20th century. The festival itself, which has recently evolved into a week-long fiesta (August 15-21), routinely offers a wide variety of events, curiosities, and novelties year after year. Cultural events such as theatre plays, handicraft fair, dance performances, classical and other concerts, puppet theatre performances, playgrounds and traditional gastronomy are waiting for visitors.
Detailed program:
The top of these event series is the Flower Carnival on August 20, the Saint Stephen’s Day, who had established the Hungarian State more than 1000 years ago, and also the day of new bread. The carnival starts at 7:30 a.m. in Petőfi Square and the floats clad in flowers and the art ensembles from home and abroad parade go along the main street of the city called Piac utca and through the city on a 5 km long route up until the Istvan Gyulai Athletic Stadium (proposed route: Petofi square, Kossuth square (Great Temple), Hatvan street, Bethlen street, Hunyadi Street, Péterfia road, Bem square, Simonyi road, Great Forest Boulevard, Gabor Olah street). Between the spectacular flower cars the invited dance groups and bands entertain the public. The parade arrives at the stadium at around 10 a.m. where the cars and the performers go around showing their best to the audience and the jury who awards the most beautiful cars and the best groups later the day. After the parade in the afternoon visitors can take a closer look at the flower cars and watch the performance of the groups in the stadium. The flower cars and the performers march through the city again in evening. They start 8:00 p.m. on the same route. Fireworks and a street party close the carnival at night. The parade is for free standing by the streets. Tickets for the Stadium and street grandstands are available at the Kölcsey Center, Apolló Cinema, Tourinform office and the Istvan Gyulai Athletic Stadium.
During the day on 20th August other colourful carnival programmes are held on several locations of the city. The “Nagyerdei” Handcraft Fair is waiting for the lovers of folk arts, traditional crafts and many other gifts along the Ady street from 8:00 till 20:00 on 20th August.
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Czech Beer Festival |
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The 2013 Czech Beer Festival now celebrates its 2nd anniversary in Debrecen. The organizers bring Hungarian and Czech breweries and beer-lovers together around the Békás Lake (Békás-tó). They prepared a selection of the best from Hungarian and Czech breweries, Czech dishes and many other Czech-related surprises waiting for the visitors. The 5-day festival (August 16 – 20) brings almost 200 domestic and international beer types to beer-lovers. Well known breweries like Budweiser 1795 along with less-known smaller breweries in top quality will showcase their products. You will have the chance to taste plenty of beer specialties, Hungarian craft beers and other alcoholic drinks like Becherovka, different cocktails, and learn about the history of beer brewing. You can enjoy live folk-music every day. The festival opens at noon and closes at midnight every day. There is no entrance fee.
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Aug. 21.
Chairman: Lóránt Székvölgyi |
08.30-09.05 B6. | Nuclear architecture studied in space and time: current state and perspectives. (Plenary lecture) | Thomas Cremer (München, Germany) |
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09.05-09.30 B7. | Barr body architecture and development studied with 3D super resolution fluorescence microscopy: X-inactivation is characterized by the collapse of a functional nuclear compartment present in active chromosome territories. | Marion Cremer (München, Germany) |
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09.30-09.55 B8. | Pronounced co-localization of immunoglobulin genes and their enhancers in transcription factories at the nuclear periphery in plasma cells. | William Garrard (Dallas, USA) |
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09.55-10.20 B9. | Nuclear topology of H3 histones revealed by structured illumination imaging. | Christian Schöfer (Vienna, Austria) |
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10.20-10.35
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Chairman: Jürgen Bode |
10.35-11.00 B10. | Regulation of transcription at PML nuclear bodies. | Peter Hemmerich (Jena, Germany) |
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11.00-11.25 B11. | Cell differentiation is dependent on Caspase-mediated genome alterations. | Lynn Megeney (Ottawa, Canada) |
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11.25-11.50 B12. | Single-strand discontinuities and R-loops mark higher-order chromatin domains. | Gábor Szabó (Debrecen, Hungary) |
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11.50-12.15 B13. | Mouse nuclear MYOSIN I knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleus. | Tomas Venit (Prague, Czech Republic) |
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12.30-14.15
| Lunch | |
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13.30-14.30
| Meeting of the International Committee | |
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14.30-16.30
| Sightseeing in Debrecen (visit to the Reformed College of Debrecen, viewing Munkácsy's Christ Trilogy in the Déri museum) | |
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17.00-23.00
| Excursion to Paripa Csárda | |
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Aug. 22.
C. Transcription, posttranscriptional processes
Chairman: Pavel Hozák |
08.30-09.05 C1. | Bimodal regulation of RNA polymerase II transcription kinetics by histone acetylation in single living cells. (Plenary lecture) | Hiroshi Kimura (Osaka, Japan) |
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09.05-09.30 C2. | Temporal and spatial characteristics of the assembly of the exon junction core complex and associated proteins on Balbani ring gene pre-mRNPs/mRNPs in vivo. | Lars Wieslander (Stockholm, Sweden) |
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09.30-09.55 C3. | Genome-wide approaches allow dissecting signal-specific transcriptional regulation. | László Nagy (Debrecen, Hungary) |
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09.55-10.20 C4. | Encode data and pervasive transcription - the question about the size of primary transcripts. | Klaus Scherrer (Paris, France) |
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10.20-10.45 C5. | Contribution of histone variant H2A.Z isoforms to transcriptional activation in hyper-acetylated chromatin. | Masayuki Kusakabe (Sendai, Japan) |
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10.45-11.00
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Chairman: Lars Wieslander |
11.00-11.25 C6. | Co-regulation of the NF-kappaB signaling pathway by Heat Shock Factor 1. | Piotr Widlak (Gliwice, Poland) |
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11.25-11.50 C7. | Reactive oxygen species and the regulation of gene expression. | Joanna Rzeszowska-Wolny (Gliwice, Poland) |
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11.50-12.15 C8. | The role of transcription factors in control of ovarian functions. | Alexander Sirotkin (Nitra, Slovakia) |
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12.15-14.00
| Lunch, poster viewing | |
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D. DNA replication, recombination, repair
Chairman: Piotr Widlak |
14.00-14.35 D1. | Replication damage induced by topoisomerase- and poly(ADPribose)polymerase-induced protein-DNA complexes. (Plenary lecture) | Yves Pommier (Bethesda, USA) |
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14.35-15.00 D2. | Topoisomerase I-DNA cleavage complexes impact on CpG island promoters. | Giovanni Capranico (Bologna, Italy) |
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15.00-15.25 D3. | Geometry and plasticity of DNA during replication: the benefit of DNA entanglements. | Jorge B. Schvartzman (Madrid, Spain) |
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15.25-15.50 D4. | Dual effect of heat shock on DNA replication and genome integrity. (Did not attend the workshop.) | Artem K. Velichko (Moscow, Russia) |
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15.50-16.05
| Break | |
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Chairman: Nikolajs Sjakste |
16.05-16.30 D5. | Chromosome organization in budding yeast: functional role towards DNA repair. | Emmanuelle Fabre (Paris, France) |
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16.30-16.55 D6. | Intrinsic homology-sensing and assembling property of chromatin. | Takashi Ohyama (Tokyo, Japan) |
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16.55-17.20 D7. | Antagonistic DNA unwinding mechanisms of RecQ helicases. | Ralf Seidel (Munster, Germany) |
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17.20-17.45 D8. | Heterochromatin Protein 1beta - a key factor in DNA repair and replication. | Jurek Dobrucki (Krakow, Poland) |
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17.45-18.10 D9. | Wag the dog: the tale of the H3K4 methylated histone tail in recombination initiation. | Lóránt Székvölgyi (Debrecen, Hungary) |
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18.10-19.45
| Dinner | |
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20.30-22.00
| Ferenc Snétberger concert[video1, video2] | |
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Aug. 23.
E. Pathological aspects, therapeutical targets
Chairman: Marion Schmidt-Zachman |
08.30-09.05 E1. | Enhancing DNA damage foci persistence to promote cancer cell senescence: targeting chromatin and metabolism. (Plenary lecture) | Stephen J. Kron (Chicago IL, USA) |
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09.05-09.30 E2. | Reversible senescence - restescence - is a unique response of breast epithelial cells to prolonged cell cycle arrest. | Dean Jackson (Manchester, UK) |
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09.30-09.55 E3. | The LINC complex in nuclear function. | Elisabeth McNally (Chicago, USA) |
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09.55-10.20 E4. | The role of amyloid in nuclear function and dysfunction. | Anna von Mikecz (Duesseldorf, Germany) |
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10.20-10.30
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Chairman: Peter Hemmerich |
10.30-10.55 E5. | Cell Cycle Control of genomic signaling. | Richard G. Pestell (Philadelphia, USA) |
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10.55-11.20 E6. | Haploinsufficiency of an Rb-E2F1-Condensin II complex causes replication stress and contributes to mesenchymal cancers. | Frederick A. Dick (London, Canada) |
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11.20-11.45 E7. | Reversible polyploidy and parasexual phenomena in tumour cells induced by DNA and spindle damage. | Jekaterina Erenpreisa (Riga, Latvia) |
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11.45-12.10 E8. | Nucleolar demethylases NO52 and NO66: important players in the development of hematological malignancies. | Marion Schmidt-Zachman (Heidelberg, Germany) |
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12.10-12.35 E9. | The role of proteinase inhibitors in the nucleus. | Natasha Kopitar-Jerala (Ljubljana, Slovenia) |
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12.35-14.00
| Lunch, poster viewing | |
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F. Novel methodical approaches
Chairman: Yosef Gruenbaum |
14.00-14.35 F1. | Changes to cellular water and ion content by nucleolar stress: investigation by a cryo-correlative nano imaging approach. (Plenary lecture) | Dominique Ploton (Reims, France) |
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14.35-15.00 F2. | Breakdown of nuclear quality control: single-cell imaging of nucleolar protein aggregation in a living organism. | Andrea Scharf (Duesseldorf, Germany) |
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15.00-15.25 F3. | Liganded RXR display highly dynamic behavior governed principally by co-activator binding as revealed by single cell imaging. | György Vámosi (Debrecen, Hungary) |
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15.25-15.40 F4. | Fluidigm products in single-cell gene expression analysis and in quantitative RT-PCR. | Radoslav Silar (BioTech-Europe, Czech Republic) |
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15.40-15.55
| Break | |
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Chairman: György Vámosi |
15.55-16.20 F5. | Specific inhibitors of nuclear transport; potential anti-virals. | David Jans (Clayton, Australia) |
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16.20-16.45 F6. | Site-specific recombinases: from tag-and-target- to tag-and-exchange-based genomic modifications. | Jürgen Bode (Hannover, Germany) |
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16.45-17.10 F7. | Antimutagenic and repair-stimulating derivative of 1,4-dihydropiridine AV-153 intercalates in DNA in a single strand break site between two pyrimidines. | Nikolajs Sjakste (Riga, Latvia) |
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17.10-17.35 F8. | ChIP efficiency is changed by fixation-induced poly(ADP)ribosylation. | Sascha Beneke (Zurich, Switzerland) |
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17.35-17.45
| Conference closing, concluding remarks | |
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18.30-
| Banquet dinner, farewell party | |
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