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Session titles
A. Nuclear architecture
B. Chromatin structure and dynamics
C. Transcription, posttranscriptional processes
D. DNA replication, recombination, repair
E. Pathological aspects , therapeutical targets
F. Novel methodical perspectives


Aug. 19.

14.00-18.00 Registration, mounting of posters[more...]

18.00-18.15 Conference opening

18.15-19.15 Nuclear architecture and disease. (Wilhelm Bernhard Medal Lecture 2013)
W1. Tom Misteli (Bethesda, USA)[more...]

A. Nuclear architecture
19.15-19.50
A1.
Nuclear organization in lymphoid cells: implications for translocations and gene regulation.
Yegor S. Vassetzky (Paris, France)

19.50-22.30 Welcome reception, poster viewing

Aug. 20.

A. Nuclear architecture
This session is offered to the memory of Ilya Zbarsky, one of the pioneers of research on nuclear architecture.[more...]
Chairman: Anna von Mikecz
08.30-09.05
A2.
From cell populations to single molecule analysis of chromosome folding. (Plenary lecture)
Peter Fraser (Cambridge, UK)

09.05-09.30
A3.
New models of the nucleus and chromosomes.
Ronald Hancock (Québec, Canada)

09.30-09.55
A4.
An interaction between telomeres and the nucleoskeleton affects chromosome structure.
Steven Kosak (Chicago, USA)

09.55-10.20
A5.
Involvement of nuclear phospholipids in nuclear structure and functions.
Pavel Hozák (Prague, Czech Republic)

10.20-10.35
Break

Chairman: Ronald Hancock
10.35-11.00
A6.
Regulation of aging and metabolism by the C. elegans nuclear lamina.
Yosef Gruenbaum (Jerusalem, Israel)

11.00-11.25
A7.
The role of eukaryotic genome spatial organization in regulation of transcription.
Sergey Razin (Moscow, Russia)

11.25-11.50
A8.
Large scale chromatin organization: the case of PcG bodies.
Ivan Raska (Prague, Czech Republic)

11.50-11.55
Reminiscences to Prof. Zbarsky
Yegor S. Vassetzky (Paris, France)

12.00-13.30
Lunch, poster viewing

Chairman: Beáta G. Vértessy
13.30-13.55
A9.
New model of nuclear pore complexes based on lipid-DNA interactions.
Vasily V. Kuvichkin (Moskow, Russia)

13.55-14.20
A10.
Putative plant homologs of lamins in plants.
Susana Moreno Díaz de la Espina (Madrid, Spain)

14.20-14.45
A11.
Actin family proteins involved in the functional organization of the nucleus.
Masahiko Harata (Sendai, Japan)

14.45-15.10
A12.
Nuclear function of a cytoskeletal actin binding protein, Moesin.
Péter Vilmos (Biological Research Center, Szeged, Hungary)

15.10-15.25
Break

B. Chromatin structure and dynamics
Chairman: Susana Moreno Díaz de la Espina
15.25-16.00
B1.
Chromatin replication and epigenome maintenance. (EMBO Young Investigator lecture)
Anja Groth (Copenhagen, Denmark)

16.00-16.25
B2.
Reconstitution of the human nuclear proteome after cell division through NLS modulation.
Beáta G. Vértessy (Budapest, Hungary)

16.25-16.50
B3.
Human inactive X chromosome is compacted through a Polycomb-independent SMACHD1-HBIX1 pathway governed by XIST RNA.
Chikashi Obuse (Hokkaido, Japan)

16.50-17.15
B4.
Lodestar loads the cohesin complex onto the chromosomes in Drosophila.
János Szabad (Szeged, Hungary)

17.15-17.40
B5.
Nucleosome-nucleosome stacking: a major element of chromatin structure.
Nikolay Korolev (Nanayng, Singapore)

Evening
Free program, cultural and touristic events of the Debrecen Flower Carnival 2013[more...] and the Czech Beer Festival[more...]

Aug. 21.

Chairman: Lóránt Székvölgyi
08.30-09.05
B6.
Nuclear architecture studied in space and time: current state and perspectives. (Plenary lecture)
Thomas Cremer (München, Germany)

09.05-09.30
B7.
Barr body architecture and development studied with 3D super resolution fluorescence microscopy: X-inactivation is characterized by the collapse of a functional nuclear compartment present in active chromosome territories.
Marion Cremer (München, Germany)

09.30-09.55
B8.
Pronounced co-localization of immunoglobulin genes and their enhancers in transcription factories at the nuclear periphery in plasma cells.
William Garrard (Dallas, USA)

09.55-10.20
B9.
Nuclear topology of H3 histones revealed by structured illumination imaging.
Christian Schöfer (Vienna, Austria)

10.20-10.35
Break

Chairman: Jürgen Bode
10.35-11.00
B10.
Regulation of transcription at PML nuclear bodies.
Peter Hemmerich (Jena, Germany)

11.00-11.25
B11.
Cell differentiation is dependent on Caspase-mediated genome alterations.
Lynn Megeney (Ottawa, Canada)

11.25-11.50
B12.
Single-strand discontinuities and R-loops mark higher-order chromatin domains.
Gábor Szabó (Debrecen, Hungary)

11.50-12.15
B13.
Mouse nuclear MYOSIN I knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleus.
Tomas Venit (Prague, Czech Republic)

12.30-14.15
Lunch

13.30-14.30
Meeting of the International Committee

14.30-16.30
Sightseeing in Debrecen (visit to the Reformed College of Debrecen, viewing Munkácsy's Christ Trilogy in the Déri museum)

17.00-23.00
Excursion to Paripa Csárda

Aug. 22.

C. Transcription, posttranscriptional processes
Chairman: Pavel Hozák
08.30-09.05
C1.
Bimodal regulation of RNA polymerase II transcription kinetics by histone acetylation in single living cells. (Plenary lecture)
Hiroshi Kimura (Osaka, Japan)

09.05-09.30
C2.
Temporal and spatial characteristics of the assembly of the exon junction core complex and associated proteins on Balbani ring gene pre-mRNPs/mRNPs in vivo.
Lars Wieslander (Stockholm, Sweden)

09.30-09.55
C3.
Genome-wide approaches allow dissecting signal-specific transcriptional regulation.
László Nagy (Debrecen, Hungary)

09.55-10.20
C4.
Encode data and pervasive transcription - the question about the size of primary transcripts.
Klaus Scherrer (Paris, France)

10.20-10.45
C5.
Contribution of histone variant H2A.Z isoforms to transcriptional activation in hyper-acetylated chromatin.
Masayuki Kusakabe (Sendai, Japan)

10.45-11.00
Break

Chairman: Lars Wieslander
11.00-11.25
C6.
Co-regulation of the NF-kappaB signaling pathway by Heat Shock Factor 1.
Piotr Widlak (Gliwice, Poland)

11.25-11.50
C7.
Reactive oxygen species and the regulation of gene expression.
Joanna Rzeszowska-Wolny (Gliwice, Poland)

11.50-12.15
C8.
The role of transcription factors in control of ovarian functions.
Alexander Sirotkin (Nitra, Slovakia)

12.15-14.00
Lunch, poster viewing

D. DNA replication, recombination, repair
Chairman: Piotr Widlak
14.00-14.35
D1.
Replication damage induced by topoisomerase- and poly(ADPribose)polymerase-induced protein-DNA complexes. (Plenary lecture)
Yves Pommier (Bethesda, USA)

14.35-15.00
D2.
Topoisomerase I-DNA cleavage complexes impact on CpG island promoters.
Giovanni Capranico (Bologna, Italy)

15.00-15.25
D3.
Geometry and plasticity of DNA during replication: the benefit of DNA entanglements.
Jorge B. Schvartzman (Madrid, Spain)

15.25-15.50
D4.
Dual effect of heat shock on DNA replication and genome integrity. (Did not attend the workshop.)
Artem K. Velichko (Moscow, Russia)

15.50-16.05
Break

Chairman: Nikolajs Sjakste
16.05-16.30
D5.
Chromosome organization in budding yeast: functional role towards DNA repair.
Emmanuelle Fabre (Paris, France)

16.30-16.55
D6.
Intrinsic homology-sensing and assembling property of chromatin.
Takashi Ohyama (Tokyo, Japan)

16.55-17.20
D7.
Antagonistic DNA unwinding mechanisms of RecQ helicases.
Ralf Seidel (Munster, Germany)

17.20-17.45
D8.
Heterochromatin Protein 1beta - a key factor in DNA repair and replication.
Jurek Dobrucki (Krakow, Poland)

17.45-18.10
D9.
Wag the dog: the tale of the H3K4 methylated histone tail in recombination initiation.
Lóránt Székvölgyi (Debrecen, Hungary)

18.10-19.45
Dinner

20.30-22.00
Ferenc Snétberger concert[video1, video2]

Aug. 23.

E. Pathological aspects, therapeutical targets
Chairman: Marion Schmidt-Zachman
08.30-09.05
E1.
Enhancing DNA damage foci persistence to promote cancer cell senescence: targeting chromatin and metabolism. (Plenary lecture)
Stephen J. Kron (Chicago IL, USA)

09.05-09.30
E2.
Reversible senescence - restescence - is a unique response of breast epithelial cells to prolonged cell cycle arrest.
Dean Jackson (Manchester, UK)

09.30-09.55
E3.
The LINC complex in nuclear function.
Elisabeth McNally (Chicago, USA)

09.55-10.20
E4.
The role of amyloid in nuclear function and dysfunction.
Anna von Mikecz (Duesseldorf, Germany)

10.20-10.30
Break

Chairman: Peter Hemmerich
10.30-10.55
E5.
Cell Cycle Control of genomic signaling.
Richard G. Pestell (Philadelphia, USA)

10.55-11.20
E6.
Haploinsufficiency of an Rb-E2F1-Condensin II complex causes replication stress and contributes to mesenchymal cancers.
Frederick A. Dick (London, Canada)

11.20-11.45
E7.
Reversible polyploidy and parasexual phenomena in tumour cells induced by DNA and spindle damage.
Jekaterina Erenpreisa (Riga, Latvia)

11.45-12.10
E8.
Nucleolar demethylases NO52 and NO66: important players in the development of hematological malignancies.
Marion Schmidt-Zachman (Heidelberg, Germany)

12.10-12.35
E9.
The role of proteinase inhibitors in the nucleus.
Natasha Kopitar-Jerala (Ljubljana, Slovenia)

12.35-14.00
Lunch, poster viewing

F. Novel methodical approaches
Chairman: Yosef Gruenbaum
14.00-14.35
F1.
Changes to cellular water and ion content by nucleolar stress: investigation by a cryo-correlative nano imaging approach. (Plenary lecture)
Dominique Ploton (Reims, France)

14.35-15.00
F2.
Breakdown of nuclear quality control: single-cell imaging of nucleolar protein aggregation in a living organism.
Andrea Scharf (Duesseldorf, Germany)

15.00-15.25
F3.
Liganded RXR display highly dynamic behavior governed principally by co-activator binding as revealed by single cell imaging.
György Vámosi (Debrecen, Hungary)

15.25-15.40
F4.
Fluidigm products in single-cell gene expression analysis and in quantitative RT-PCR.
Radoslav Silar (BioTech-Europe, Czech Republic)

15.40-15.55
Break

Chairman: György Vámosi
15.55-16.20
F5.
Specific inhibitors of nuclear transport; potential anti-virals.
David Jans (Clayton, Australia)

16.20-16.45
F6.
Site-specific recombinases: from tag-and-target- to tag-and-exchange-based genomic modifications.
Jürgen Bode (Hannover, Germany)

16.45-17.10
F7.
Antimutagenic and repair-stimulating derivative of 1,4-dihydropiridine AV-153 intercalates in DNA in a single strand break site between two pyrimidines.
Nikolajs Sjakste (Riga, Latvia)

17.10-17.35
F8.
ChIP efficiency is changed by fixation-induced poly(ADP)ribosylation.
Sascha Beneke (Zurich, Switzerland)

17.35-17.45
Conference closing, concluding remarks

18.30-
Banquet dinner, farewell party


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